Seroconversion are the amount of feminine seronegative at the standard and seropositive from the follow-right up some of those seronegative from the baseline
Statistical strategies
For the following analyses, “one HPV” makes reference to seropositivity otherwise DNA positivity for at least certainly the second Hours-HPV versions: 16, 18, 31, 33, thirty five, forty five, 52, and you may 58.
Any, type-specific and age-specific ( < 20,>=61 years) HR-HPV seroprevalence (at baseline and follow-up), seropersistence, seroclearance and seroconversion (at follow-up) were assessed. Seropersistence was defined as the number of women who were seropositive at baseline and follow-up among all women who were seropositive at baseline. Seroclearance was the number of women who were seropositive at baseline and seronegative at follow-up among all those seropositive at baseline.
Standard seropositivity is weighed against concurrent cervical DNA positivity to assess concordance, that can simply be checked on method of-specific peak, since ladies are commonly infected having numerous style of HPV and you will the fresh concordance reputation are other for each and every type of. To overcome such as for example limitation, analyses had been did in the genotype top having fun with general estimating picture (GEE) models you to take into account having less independence between several findings regarding the exact same lady [twenty two, 23].
Univariable and multivariable GEE models were performed to identify predictors of HR-HPV seroprevalence at baseline. Risk estimates were adjusted by potential risk factors for HPV seropositivity: age at baseline, marital status, education level, number of children, age at first sexual intercourse, lifetime number of sexual partners, high-risk sexual partner (who engaged in extra-relationship sexual activity), history of sexually transmitted disease, hormonal contraception, smoking, condom use and cervical HR-HPV DNA infection.
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